SEC-MALS Services
SEC-MALS (Size Exclusion Chromatography – Multi Angle Light Scattering)
GMP/GLP Large Molecule Testing Services
With the growing number of large molecule products in development, it is more important than ever to be able to characterize your large molecule product with confidence.
That is why Dalton has added GMP/GLP Size Exclusion Chromatography – Multi Angle (Laser) Light Scattering (SEC-MALS) to its analytical services offering.
SEC-MALS is an established analytical method for the absolute determination of molar mass of large molecules. This approach is ideal for molecules with molar masses ranging from 103 to 109 g/mol, and is suitable for many molecule types such as:
- Proteins
- Peptides
- Conjugates
- Polymers
- Biopolymers
SEC-MALS Advantages
SEC-MALS can replace a number of traditional techniques, such as viscosity, electrophoresis and retention times by HPLC, with a single absolute test.
- Fast –Results in as little as one hour making it viable as an in-process test
- Absolute – Molar mass is an absolute measure, not relative to a standard
- Automated – Efficient and can process multiple samples quickly
- Reliable – Precise and accurate molar mass results
- Established – Accepted GMP/GLP test, no additional regulatory hurdles for validated methods
SEC-MALS Services
We Develop, Validate and Test:
- GMP/GLP Compliant Services
- Analytical Method Development
- Method Validation
- Release Testing
- In-Process Testing
- Stand-Alone Analytical Testing
With a rapid turnaround time and an automated process, Dalton's GMP/GLP SEC-MALS services can provide you with the accurate and precise molecular mass results you need for your large molecule.
Dalton uses state of the art Wyatt MALS (light scattering) and Refractive Index (RI) detectors in combination with Agilent HPLCs in our GMP/GLP analytical laboratories. The automated system allows for the efficient testing of multiple samples. With rapidly available test results, SEC-MALS can be a viable option for both your in-process and product testing requirements.
Contact us for more information on our SEC-MALS services.