Structure Elucidation of Impurities
With over 2,000 high quality research molecules in our catalogue, Dalton has over 30 years of expertise in structure elucidation of unknown synthetic impurities, intermediates, degradants, and excipient-related impurities.
Impurity Screening:
Identification of Unknown impurities of >0.05% abundance using internally developed or client supplied method.
Structure Elucidation Capabilities:
LC/MS/MS, FTIR, HRMS, 1D& 2D NMR, Chiral Chromatography
Isolation Techniques: Preparative HPLC, SPE, SPME, and wet chemistry procedures.
Custom Synthesis:
Our creative and highly skilled synthetic chemists can quickly turn around custom synthesis in projects to verify the final structure of the impurity.
Impurity Reference Standards:
Identified compounds can be ultra-purified for use as reference standards for QC analysis and stability impurity monitoring studies.
Timeline:
Reliable preliminary screening in 2-3 weeks or less per sample. Projects can be extended to custom synthesis, structure verification, process development, and small and medium scale production. (Expedited services available upon request).
Deliverables:
Compliant data and executed documents. CoA available upon request.